The survival and persistence of endometrial implants is maintained by the presence of estrogen hormones. These estrogen-dependent lesions, grow and regress as the estrogen level fluctuating up and down respectively. As it regresses, inflammation occurs and leads to release of various inflammatory mediators which responsible for the pain symptoms in endometriosis. These mediators lead to damage of the surrounding tissues and when healing process take places later, there will be scarring and adhesion which increase the severity and complication of the disease.
Depending on the location of the endometrial implants, the pain symptoms may vary in term of presentation, commonly such as: 1) dysmenorrhea 2) dyspareunia 3) dyschezia 4) dysuria 5) lower abdominal / back pain. Some women may presented with more atypical presentation which may suggest more invasive disease such as hematuria (bladder invasion), hematochezia (bowel invasion), sciatica (nerve invasion), or dyspnea (catamenial pneumothorax).
Endometriosis is a chronic relapsing progressive disorder. as the disease progresses, patient may develop chronic pelvic pain due to the chronic inflammatory process. Besides,patient may suffer from subfertility with all the adhesion which may cause mechanical obstruction of the reproductive route preventing fertilization or implantation to occur properly.
Depending on the location of the endometrial implants, the pain symptoms may vary in term of presentation, commonly such as: 1) dysmenorrhea 2) dyspareunia 3) dyschezia 4) dysuria 5) lower abdominal / back pain. Some women may presented with more atypical presentation which may suggest more invasive disease such as hematuria (bladder invasion), hematochezia (bowel invasion), sciatica (nerve invasion), or dyspnea (catamenial pneumothorax).
Endometriosis is a chronic relapsing progressive disorder. as the disease progresses, patient may develop chronic pelvic pain due to the chronic inflammatory process. Besides,patient may suffer from subfertility with all the adhesion which may cause mechanical obstruction of the reproductive route preventing fertilization or implantation to occur properly.
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